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KMID : 0869619990160040507
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Journal of Korean Society of Hospital Pharmacists
1999 Volume.16 No. 4 p.507 ~ p.511
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Compatibility Test of Vancomycin and Heparin in a Total Parenteral Nutrition Solution
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김미경/Kim, Mi Kyung
정양희/김재연/김승란/노환성/Jeong, Yang Hee/Kim, Jae Youn/Kim, Seoung Lan/Ro, Hwan Seong
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Abstract
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Vancomycin (VANC), a glycopeptide antibiotic used for the treatment of patients with infections caused by Staphylococcal species and Streptococcal species, is incompatible with heparin (concentration > 1.0 U/㎖). Even though heparin concentration in TPN solutions administered in AMC (Asan Medical Center) is 0.25 U/㎖, beyond 1.0 U/㎖, we have stopped administration of TPN during the VANC infusion time because of the absence of experimental sources. So, we studied the compatibility of VANC and heparin in TPN.
We observed the variations before and after admixing VANC and heparin (in TPN) by examining with the naked eye under a microscope of 400 magnifications, measuring the concentration of VANC and the heparin activity.
RESULT : ① We could not distinguish the variations under the microscope (× 400).
② As a result of measuring the concentration of VANC by HPLC (UV detector 225㎚, C_(18) Column, Mobile phase acetonitrile : 0.01 M 1-heptane sulfonic acid = 12 : 88, Flow rate 2.0 ㎖/min), there is no significant difference between before and after (% change of peak area from standard sample : 102.61%, 101.03% respectively / P-value = 0.464).
③ However, according to the results of measuring the heparin activity by APTT, anticoagulant action of heparin in TPN was reduced by VANC.
Therefore, the simultaneous administration of TPN (heparin 0.25 U/㎖) and VANC via a Y-site is judged to be inadequate.
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